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Patch Clamping hERG: Validation of an Automated Patch Clamp Assay |
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[187 kB] |
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GIT-Trends in Drug Discovery 8(3):30–33, 2007:
A common reason for attrition in drug development is the risk of acquired long-QT syndrome. The hERG-potassium channel
is believed to mediate this adverse effect. We report the design of a hERG assay running on
an automated patch-clamp robot including the generation of a customized cell line,
an appropriate stimulus protocol, and pharmacological validation. The assay proved to be valuable
for medium-scale screening in the lead optimization phase. |
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AUTOMATED
PATCH CLAMPING setting a new standard for early hERG |
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[7 MB] |
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Article in Drug Discovery World,
Winter 2005/6:
Ion channel targets remain a top priority for many Pharma and
Biotechs with most looking to increase their screening efforts
in 2006.The impact of automated patch clamping (APC) on ion
channel screening is now evident, particularly in early non-compliant
hERG liability testing, where APC is rapidly becoming the new
‘gold standard’ technology. |
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Patch
Clamping by numbers |
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[227 kb] |
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Article in Drug Discovery Today,
Vol. 9, No. 10, May 2004:
Many ion channels are recognized as amenable targets for a
range of disease states and conditions. However, the process
of discovering drugs is highly influenced by the chemical doability,
the biological confidence in rationale of the approach and
the 'screenability'. |
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Patchers
versus Screeners: Divergent opinion on high throughput electrophysiology
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[328 kb] |
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Article in Drug Discovery World,
Fall 2003:
The prospect of enabling higher throughput electro-physiology
(patch-clamping) has created much expectation from scientists
within the ion channel community. Yet there are opposing views
among traditional electrophysiologists and screeners as to the
needed specification and the preferred mode of operation or
such devices. |
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