hERG Safety Assessment
Recently several successfully marketed drugs had to be withdrawn due to severe side effects from hERG channel blockage. The
block of this potassium channel may result in a prolongation of the QT interval and could lead to the polymorphic ventricular tachyarrhythmia
(Torsade de Pointes), potentially causing death of the patient by cardiac arrest. A list of the most prominent drugs can be found at Arizona CERT (Torsades).
In order to avoid this side effect, the FDA has issued guidelines
(ICH 7B ) for a non-clinical evaluation of prospective drugs, detailing the means of how to screen for a risk of QT interval prolongation.
The gold standard method to study ionic currents through ion channels is the patch-clamp method. It is the only direct technique which
allows real time analysis of ion channel function at a high resolution.
flyion´s "Flip-the-Tip" automated patch-clamp technology provides a high-quality and cost-efficient hERG screen using its own
in-house created CHO-hERG cell line.
Located in Tübingen, Germany, flyion GmbH offers fast, confidential, and customer specific hERG safety assessments and pharmacological
profiling services.
For more information please use the following link: hERG Safety Assessment or contact us for pricing.
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